Endogenous Cholinergic Anti‐Inflammatory Pathway in Hepatic Ischemia‐Reperfusion (IR)
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چکیده
منابع مشابه
Fat meets the cholinergic antiinflammatory pathway
The cholinergic antiinflammatory pathway is a neural mechanism that is controlled by the vagus nerve and inhibits local cytokine release, thereby preventing the damaging effects of cytokine overproduction. A new study now shows that dietary fat can activate this pathway, a finding that may help explain the immune system's failure to react to food antigens and commensal bacteria. Here we discuss...
متن کاملPharmacological Stimulation of the Cholinergic Antiinflammatory Pathway
Efferent activity in the vagus nerve can prevent endotoxin-induced shock by attenuating tumor necrosis factor (TNF) synthesis. Termed the "cholinergic antiinflammatory pathway," inhibition of TNF synthesis is dependent on nicotinic alpha-bungarotoxin-sensitive acetylcholine receptors on macrophages. Vagus nerve firing is also stimulated by CNI-1493, a tetravalent guanylhydrazone molecule that i...
متن کاملRole of the cholinergic antiinflammatory pathway in murine autoimmune myocarditis.
RATIONALE This study was performed to gain insights into novel therapeutic approaches for the treatment of autoimmune myocarditis. OBJECTIVE Chemical stimulation of the efferent arm of the vagus nerve through activation of nicotinic acetylcholine receptor subtype-7α (α7-nAChR) has been shown to be protective in several models of inflammatory diseases. In the present study, we investigated the...
متن کاملPhysiology and immunology of the cholinergic antiinflammatory pathway.
Cytokine production by the immune system contributes importantly to both health and disease. The nervous system, via an inflammatory reflex of the vagus nerve, can inhibit cytokine release and thereby prevent tissue injury and death. The efferent neural signaling pathway is termed the cholinergic antiinflammatory pathway. Cholinergic agonists inhibit cytokine synthesis and protect against cytok...
متن کاملPutting out fat's fire with the cholinergic antiinflammatory pathway.
A compelling body of research over the last two decades has established that chronic inflammation in adipose tissue makes a key contribution to insulin resistance in obesity (reviewed in Ref. 1). Adipocyte expansion in obesity is frequently accompanied by an induction of inflammatory mediators and cytokines, including (but not limited to) TNF (2), IL-1 and IL-6, plasminogen activator inhibitor-...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.709.10